The NMO (Aquaporin-4) IgG Test is a blood test used to detect Aquaporin-4 (AQP4) IgG antibodies, which are associated with Neuromyelitis Optica Spectrum Disorder (NMOSD). This autoimmune disorder primarily affects the optic nerves and spinal cord, leading to symptoms like vision loss and paralysis.
✅ Diagnose Neuromyelitis Optica Spectrum Disorder (NMOSD)
✅ Differentiate NMOSD from Multiple Sclerosis (MS) (as both can have similar symptoms)
✅ Assess Unexplained Optic Neuritis, Transverse Myelitis, or Brainstem Syndromes
✅ Guide Treatment Decisions – Helps in selecting appropriate immunosuppressive therapies
| Test Result | Interpretation | Condition |
|---|---|---|
| Positive (AQP4-IgG Detected) | Confirms NMOSD | Neuromyelitis Optica Spectrum Disorder |
| Negative (No AQP4-IgG Detected) | NMOSD unlikely, but not ruled out | Could be MS, MOGAD, or another disorder |
📌 About 70-80% of NMOSD patients test positive for AQP4-IgG.
📌 A negative test does not exclude NMOSD, as some cases are caused by MOG (Myelin Oligodendrocyte Glycoprotein) antibodies instead.
| Feature | NMOSD (AQP4-IgG Positive) | Multiple Sclerosis (MS) |
|---|---|---|
| Antibody | AQP4-IgG positive in ~80% | Oligoclonal bands (OCBs) in CSF |
| Affected Areas | Optic nerve, spinal cord, brainstem | Brain, spinal cord |
| MRI Findings | Long spinal cord lesions (3+ vertebrae) | Smaller brain/spinal lesions |
| Relapses | More severe attacks, incomplete recovery | Frequent relapses but slower progression |
| Treatment | Immunosuppressants (e.g., rituximab) | MS therapies (interferons, fingolimod, etc.) |
🔬 Additional Tests:
✔ MRI Brain & Spine – Identifies characteristic NMOSD lesions
✔ Lumbar Puncture (CSF Analysis) – Checks for oligoclonal bands (which are common in MS but rare in NMOSD)
✔ MOG-IgG Test – Helps rule out MOG-associated disease (MOGAD)
💊 Treatment Options:
Original price was: ₹6,300.00.₹4,999.00Current price is: ₹4,999.00.