The Phospholipase A2 Receptor (PLA2R) Antibody Test is used to diagnose and monitor primary membranous nephropathy (pMN), a kidney disease that causes protein loss in urine (proteinuria) and can lead to chronic kidney disease (CKD).
✅ Diagnose primary membranous nephropathy (pMN) – The most common cause of nephrotic syndrome in adults
✅ Differentiate primary MN from secondary MN (caused by lupus, infections, or medications)
✅ Monitor disease activity and treatment response
✅ Predict the risk of disease relapse
| Test Result | Interpretation |
|---|---|
| Negative (<2 RU/mL) | No significant antibodies detected |
| Borderline (2–20 RU/mL) | Possible early or mild disease |
| Positive (>20 RU/mL) | Suggests active primary membranous nephropathy |
📌 Higher PLA2R antibody levels correlate with more severe disease and higher proteinuria.
🔹 Primary Membranous Nephropathy (pMN) – 70-80% of pMN patients test positive
🔹 Rarely seen in secondary MN – Helps distinguish between primary and secondary causes
🔹 Chronic Kidney Disease (CKD) with nephrotic syndrome – If due to pMN
📌 A negative result does NOT rule out pMN, especially in later stages where antibody levels may decline.
⚠ Signs of kidney damage and protein loss:
✔ Severe proteinuria (foamy urine)
✔ Swelling (edema) – Especially in legs, ankles, and around the eyes
✔ High blood pressure (hypertension)
✔ Increased cholesterol levels
✔ Risk of blood clots (due to protein loss)
🔬 Confirmatory Tests:
✔ 24-hour urine protein test – Measures protein loss
✔ Kidney biopsy – Confirms membranous nephropathy and checks for immune deposits
✔ Serum creatinine & GFR – Evaluates kidney function
✔ Complement levels (C3, C4) – Helps rule out lupus-related MN
💊 Treatment Options:
✔ Immunosuppressive Therapy – Corticosteroids, rituximab, cyclophosphamide
✔ Supportive Care – ACE inhibitors/ARBs (to reduce protein loss), diuretics (for edema), statins (for high cholesterol)
✔ Monitoring PLA2R Antibody Levels – A decline suggests treatment response, while persistent high levels indicate a risk of relapse
Original price was: ₹6,500.00.₹5,399.00Current price is: ₹5,399.00.