Metanephrine Test – Details & Precautions

The Metanephrine Test measures metanephrines (metanephrine & normetanephrine) in blood or urine to help diagnose pheochromocytoma and paraganglioma—rare tumors that produce excessive adrenaline and noradrenaline.

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Details of the Metanephrine Test

Purpose

• Diagnoses pheochromocytomas (adrenal gland tumors) and paragangliomas (nerve tissue tumors).
• Detects excess adrenaline (epinephrine) and noradrenaline (norepinephrine) levels.
• Evaluates high blood pressure (hypertension) that may be due to hormonal imbalances.
• Monitors patients with a history of pheochromocytoma for recurrence.

Types of Tests

1. Plasma Free Metanephrine Test (Blood Test)

• Measures metanephrine and normetanephrine in the bloodstream.
• More sensitive for detecting pheochromocytomas.

2. 24-Hour Urine Metanephrine Test

• Collects all urine produced in 24 hours to measure metanephrines.
• Used when blood test results are unclear.

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Precautions for the Metanephrine Test

Before the Test

✅ Fasting:

• Blood test: Fast for at least 8–10 hours before the test (only water is allowed).
• Urine test: No fasting is required.

✅ Dietary Restrictions (24–48 hours before test):

• Avoid caffeine (coffee, tea, energy drinks, cola).
• Avoid bananas, chocolate, vanilla, nuts, and alcohol as they can affect results.

✅ Medication Restrictions:

• Inform your doctor about blood pressure medications, antidepressants, and decongestants, as they can interfere with the test.
• If possible, stop epinephrine, norepinephrine, dopamine, and amphetamine-based medications under doctor supervision.

✅ Avoid Stress & Physical Activity (24 hours before test):

• Stress, exercise, and anxiety can increase metanephrine levels.
• Stay calm and avoid intense physical activity before the test.

During the Test

• Blood test: A small sample is taken from a vein; mild pain or bruising may occur.
• Urine test: Collect all urine over 24 hours in a provided container.

After the Test

✅ Resume normal activities immediately.
✅ Monitor blood pressure if you have a history of hypertension.

REPORTS – TUS / THUS/ SAT.