Test Name: Del[13q] (MM, CLL)
Sample Type: Bone Marrow / Peripheral Blood
Collection Container: Sodium Heparin Vacutainer
Volume Required: 2 mL

4-5  days reports final

Clinical Use:
Detection of deletion 13q, commonly associated with:

• Multiple Myeloma (MM)

• Chronic Lymphocytic Leukemia (CLL

Test Name:

Del[13q] (MM, CLL)

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Clinical Significance:

The Del[13q] (Deletion of the long arm of chromosome 13) is a cytogenetic abnormality frequently observed in hematological malignancies, notably:

• Multiple Myeloma (MM)

• Chronic Lymphocytic Leukemia (CLL)

In MM:
Del[13q] is often associated with a poor prognosis and is linked with high-risk disease features.

In CLL:
Del[13q] is the most common chromosomal abnormality and is typically associated with a favorable prognosis, particularly when it is the sole abnormality.

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Sample Requirements:

• Sample Type: Bone Marrow / Peripheral Blood

• Collection Tube: Sodium Heparin Vacutainer

• Volume: 2 mL

• Transport Conditions: Ambient temperature; avoid freezing.

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Methodology:

• Fluorescence In Situ Hybridization (FISH)
  FISH is used to detect deletions at the 13q14 region with high sensitivity.

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Turnaround Time:

7–10 working days

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Indications for Testing:

• Newly diagnosed or relapsed Multiple Myeloma or CLL

• Baseline cytogenetic profiling

• Prognostic stratification

• Monitoring disease progression

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Interpretation:

• Positive Result: Indicates deletion of 13q region — prognosis depends on clinical context (MM vs. CLL).

• Negative Result: No deletion detected — other genetic abnormalities may still be present.