Sex Hormone Binding Globulin (SHBG) Test

The Sex Hormone Binding Globulin (SHBG) test measures the level of SHBG in the blood. SHBG is a protein produced by the liver that binds to sex hormones like testosterone, estrogen, and dihydrotestosterone (DHT), controlling their availability in the body.

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Why is the Test Done?

A doctor may order an SHBG test to evaluate:

✅ Hormonal Imbalances (e.g., low testosterone, high estrogen)
✅ Polycystic Ovary Syndrome (PCOS) in women
✅ Hypogonadism (low testosterone levels) in men
✅ Erectile Dysfunction (ED) and decreased libido
✅ Hirsutism (excess facial/body hair) in women
✅ Infertility (both men and women)
✅ Hormonal conditions like thyroid disorders or insulin resistance

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How is the Test Done?

1. Blood Sample Collection:

   • A blood sample is drawn from a vein.
   • Sent to a lab for analysis.

2. Lab Analysis:

   • Measures SHBG levels in nanomoles per liter (nmol/L).

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Normal SHBG Levels

(Normal ranges may vary by lab and individual factors)

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Interpreting the Results

📌 Note:

• SHBG affects how much free (active) testosterone is available in the body.
• A high SHBG level can mean less free testosterone, leading to low libido, fatigue, and muscle loss.
• A low SHBG level can indicate excess testosterone, often seen in PCOS or insulin resistance.

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Next Steps After an Abnormal Result

🔬 Additional Tests May Be Ordered:

• Total & Free Testosterone – To assess available testosterone.
• Estrogen Levels (Estradiol, E2) – Especially in women with PCOS or men with gynecomastia.
• Thyroid Function Tests (T3, T4, TSH) – If thyroid issues are suspected.
• Insulin & Glucose Tests – To check for insulin resistance or diabetes.

💊 Treatment & Management:

• Lifestyle Changes (Diet & Exercise) – Can help regulate SHBG and hormone balance.
• Hormonal Therapy – For conditions like low testosterone or PCOS.
• Medications (e.g., Metformin for insulin resistance, Thyroid medications for hypothyroidism)