Original price was: ₹5,000.00.₹3,999.00Current price is: ₹3,999.00.
The Desmoglein III Antibody (DSG3 Ab) test detects autoantibodies against Desmoglein-3, a protein that helps skin cells stick together. This test is primarily used to diagnose Pemphigus Vulgaris (PV), an autoimmune blistering skin disease.
✅ To diagnose Pemphigus Vulgaris (PV), an autoimmune skin disorder
✅ To differentiate Pemphigus Vulgaris from other blistering diseases
✅ To monitor disease activity and treatment response
| Result | Interpretation |
|---|---|
| Negative (<20 U/mL) | No significant antibodies detected (Normal) |
| Borderline (20-30 U/mL) | Possible mild or early disease |
| Positive (>30 U/mL) | Strong indication of Pemphigus Vulgaris (PV) |
🔴 High levels (>30 U/mL) → Pemphigus Vulgaris (PV) likely
🔴 Desmoglein I & III Antibodies together → More widespread disease (Mucocutaneous PV)
🔴 Monitoring levels → Helps track disease progression or treatment response
⚠ Painful blisters in the mouth & skin
⚠ Erosions that don’t heal easily
⚠ Skin peeling with minimal pressure (Nikolsky’s Sign)
⚠ Difficulty eating/swallowing if mouth is affected
🔹 Desmoglein I Antibody – Helps differentiate from Pemphigus Foliaceus
🔹 Skin Biopsy with Direct Immunofluorescence (DIF) – Confirms autoantibody deposits
🔹 Indirect Immunofluorescence (IIF) – Detects circulating autoantibodies
🔹 ELISA for DSG1 & DSG3 – Quantifies autoantibody levels
✔ Corticosteroids (Prednisone) – First-line treatment
✔ Immunosuppressants (Azathioprine, Mycophenolate Mofetil) – To control autoimmunity
✔ Rituximab (Biologic Therapy) – Effective in severe cases
✔ Wound care & pain management – Prevents infections