Original price was: ₹4,750.00.₹3,999.00Current price is: ₹3,999.00.
The Desmoglein I (DSG1) Antibody test detects autoantibodies against Desmoglein-1, a protein responsible for skin cell adhesion. This test is primarily used to diagnose Pemphigus Foliaceus (PF), an autoimmune blistering skin disorder.
✅ To diagnose Pemphigus Foliaceus (PF), a skin blistering disease
✅ To differentiate Pemphigus Foliaceus from Pemphigus Vulgaris (PV)
✅ To monitor disease progression and treatment response
| Result | Interpretation |
|---|---|
| Negative (<20 U/mL) | No significant antibodies detected (Normal) |
| Borderline (20-30 U/mL) | Possible mild or early disease |
| Positive (>30 U/mL) | Strong indication of Pemphigus Foliaceus (PF) |
🔴 High levels (>30 U/mL) → Suggests Pemphigus Foliaceus (PF)
🔴 Desmoglein I & III Antibodies together → Indicates more severe disease (Mucocutaneous Pemphigus)
🔴 Monitoring levels → Helps track disease activity and response to treatment
| Feature | Pemphigus Foliaceus (PF) | Pemphigus Vulgaris (PV) |
|---|---|---|
| Desmoglein Antibody | DSG1+ | DSG3+ (sometimes DSG1+) |
| Blister Location | Superficial (Skin only) | Deep blisters (Mucosa + Skin) |
| Pain Level | Mild to moderate | Severe, especially in mouth |
| Nikolsky’s Sign | Positive | Positive |
âš Superficial blisters on the face, scalp, and trunk
âš Flaky, crusty skin lesions
âš No involvement of the mouth or mucous membranes
âš Skin peels easily (Positive Nikolsky’s Sign)
🔹 Desmoglein III Antibody Test – To rule out Pemphigus Vulgaris (PV)
🔹 Skin Biopsy with Direct Immunofluorescence (DIF) – Confirms antibody deposits
🔹 Indirect Immunofluorescence (IIF) – Detects circulating autoantibodies
🔹 ELISA for DSG1 & DSG3 – Quantifies antibody levels
✔ Corticosteroids (Prednisone) – First-line treatment
✔ Immunosuppressants (Azathioprine, Mycophenolate Mofetil) – To control autoimmunity
✔ Rituximab (Biologic Therapy) – Effective for severe cases
✔ Topical steroids & wound care – Helps manage skin lesions