The ASCA IgG antibody test detects IgG antibodies against Saccharomyces cerevisiae, a type of yeast. This test is primarily used to help diagnose inflammatory bowel disease (IBD), particularly Crohn’s disease (CD), and to differentiate it from ulcerative colitis (UC).
✅ Aid in the diagnosis of Crohn’s disease
✅ Differentiate Crohn’s disease from ulcerative colitis
✅ Assess IBD severity and progression
| Result | Interpretation |
|---|---|
| Negative | No significant ASCA IgG detected, less likely to be Crohn’s disease |
| Borderline | Possible low-level antibodies, may need further testing |
| Positive | Suggestive of Crohn’s disease, especially if ASCA IgA is also positive |
🔹 ASCA IgG and ASCA IgA are more common in Crohn’s disease (CD) than in ulcerative colitis (UC).
🔹 Up to 60-70% of Crohn’s disease patients test positive for ASCA.
🔹 Only 10-15% of ulcerative colitis (UC) patients have ASCA positivity.
Crohn’s Disease (CD) → Higher ASCA positivity, especially in small bowel involvement.
Ulcerative Colitis (UC) → ASCA is usually negative, but pANCA is often positive.
IBD Diagnosis Aid → ASCA (+) & pANCA (-) suggests Crohn’s disease, while ASCA (-) & pANCA (+) suggests ulcerative colitis.
✔ ASCA IgA → Often tested alongside IgG for better accuracy.
✔ pANCA (Perinuclear Anti-Neutrophil Cytoplasmic Antibodies) → More common in ulcerative colitis.
✔ Fecal Calprotectin & Lactoferrin → Indicate intestinal inflammation.
✔ Endoscopy with Biopsy → Definitive test to confirm IBD and differentiate CD from UC.
🔹 Evaluate symptoms (diarrhea, abdominal pain, weight loss, fistulas).
🔹 Consider additional testing (ASCA IgA, pANCA, stool tests, imaging, or colonoscopy).
🔹 Discuss with a gastroenterologist for IBD management.
Original price was: ₹1,750.00.₹1,399.00Current price is: ₹1,399.00.