The Anti-Sperm Antibody (ASA) test detects antibodies that attack sperm, potentially leading to male or female infertility. These antibodies can develop in men or women and interfere with sperm movement, function, or fertilization.
✅ Evaluate unexplained infertility in men or women
✅ Assess immune-related causes of sperm dysfunction
✅ Investigate post-vasectomy reversal infertility
✅ Identify potential immune reactions after testicular injury or infection
| Result | Interpretation |
|---|---|
| Negative | No significant anti-sperm antibodies detected |
| Low Positive | Minor presence of antibodies, may not significantly impact fertility |
| High Positive | Strongly suggests an immune-related cause of infertility |
🔹 Men: Anti-sperm antibodies may coat sperm, preventing movement and reducing fertilization chances.
🔹 Women: The immune system may attack sperm, making conception difficult.
In Men:
Vasectomy or vasectomy reversal
Testicular injury or surgery
Genital infections
Prostatitis (inflammation of the prostate)
In Women:
Immune system disorders
Repeated exposure to sperm (e.g., multiple partners, allergic reactions)
✔ Semen Analysis → Checks sperm count, motility, and morphology.
✔ Post-Coital Test → Examines how sperm interact with cervical mucus.
✔ Sperm Penetration Assay → Evaluates the sperm’s ability to fertilize an egg.
✔ Hysterosalpingography (HSG) → Assesses female reproductive tract for blockages.
✔ Hormone Testing (FSH, LH, Testosterone, Estrogen, Progesterone, Prolactin) → Evaluates fertility-related hormones.
🔹 Corticosteroids or Immunosuppressants → Reduce immune response (rarely used).
🔹 Intrauterine Insemination (IUI) → Bypasses cervical mucus to increase fertilization chances.
🔹 In Vitro Fertilization (IVF) with Intracytoplasmic Sperm Injection (ICSI) → Helps sperm bypass antibodies and directly fertilize an egg.
🔹 Sperm Washing → Removes antibodies from sperm before insemination.