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Anti-ds DNA

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Anti-Double-Stranded DNA (Anti-dsDNA) Antibody Test – Detailed Guide

The Anti-dsDNA Antibody Test detects autoantibodies against double-stranded DNA, which are strongly associated with Systemic Lupus Erythematosus (SLE). These antibodies attack the body’s own DNA, leading to inflammation, organ damage, and autoimmune reactions.

Why is the Anti-dsDNA Test Done?

✅ To Diagnose Systemic Lupus Erythematosus (SLE)

  • Highly specific for SLE (Lupus), unlike the ANA (Antinuclear Antibody) Test, which can be positive in many conditions
  • Helps confirm SLE diagnosis in ANA-positive patients

✅ To Assess Disease Activity & Flare-Ups in Lupus

  • Higher Anti-dsDNA levels often indicate active disease, especially kidney involvement (Lupus Nephritis)

✅ To Monitor Treatment Response in SLE

  • Helps evaluate effectiveness of medications and disease progression

Test Procedure

🩸 Blood Sample Collection:

  • A blood sample is drawn from a vein
  • No fasting required
  • Results available in 2–5 days

Normal Range & Interpretation

Result Value (IU/mL or U/mL) Interpretation
Negative < 30 IU/mL No significant Anti-dsDNA antibodies detected
Borderline 30 – 75 IU/mL Possible autoimmune activity (needs further evaluation)
Positive > 75 IU/mL Strongly suggests SLE (Lupus)

🔹 Higher levels indicate more active lupus, especially kidney involvement (Lupus Nephritis).
🔹 Low or negative Anti-dsDNA does not completely rule out SLE.

What Do Abnormal Anti-dsDNA Antibody Levels Mean?

🔴 High Anti-dsDNA Levels (> 75 IU/mL) May Indicate:

  • Systemic Lupus Erythematosus (SLE) – Most common cause
  • Lupus Nephritis – If kidney involvement is suspected
  • Other autoimmune diseases (rare cases) – Mixed connective tissue disease, Sjögren’s syndrome

🟢 Low or Negative Anti-dsDNA (< 30 IU/mL):

  • Unlikely to have active lupus
  • Can still have SLE if other autoantibodies are positive (e.g., ANA, Anti-Sm)

Next Steps If Anti-dsDNA Is Positive?

🔬 Further Tests May Be Needed:

  • ANA (Antinuclear Antibody) Test – Often the first test for lupus
  • C3 & C4 Complement Levels – Low levels suggest active lupus
  • ESR & CRP (Inflammation Markers) – To assess disease activity
  • Kidney Function Tests (Creatinine, Urinalysis, Proteinuria) – To check for Lupus Nephritis

✅ Treatment for Lupus May Include:

  • Immunosuppressants: Hydroxychloroquine, methotrexate, mycophenolate
  • Corticosteroids: To reduce inflammation in severe cases
  • Biologic Therapies: Belimumab, Rituximab for resistant cases
  • Lifestyle Modifications: Sun protection, stress management, healthy diet

Original price was: ₹1,399.00.Current price is: ₹749.00.

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