Aspergillus IgG

Aspergillus IgG Antibody Test: Overview

The Aspergillus IgG antibody test detects IgG antibodies against Aspergillus species, a genus of fungi that can cause chronic lung infections and allergic reactions. It is primarily used to diagnose chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA).


Purpose of the Test

Diagnosing chronic pulmonary aspergillosis (CPA)
Assessing allergic bronchopulmonary aspergillosis (ABPA)
Distinguishing active infection from colonization


Interpreting Results

Result Interpretation
Negative No significant Aspergillus IgG detected (infection unlikely)
Borderline/Indeterminate Possible early or low-level infection, may need repeat testing
Positive Suggestive of past or current Aspergillus exposure, CPA, or ABPA

🔹 False positives may occur due to cross-reactivity with other fungal infections.
🔹 False negatives can occur in immunocompromised patients who do not mount a strong antibody response.


Clinical Significance

  • Chronic Pulmonary Aspergillosis (CPA) → A long-term lung infection in people with pre-existing lung disease (e.g., TB, COPD, bronchiectasis).

  • Allergic Bronchopulmonary Aspergillosis (ABPA) → A hypersensitivity reaction seen in asthma and cystic fibrosis patients.

  • Aspergilloma (Fungal Ball) → A localized fungal mass in a lung cavity, often in patients with previous lung damage.


Additional Diagnostic Tests

Aspergillus IgM → May indicate recent or active infection.
Galactomannan Antigen Test → Preferred for detecting invasive aspergillosis.
Beta-D-Glucan Test → Broad fungal infection marker but not Aspergillus-specific.
Fungal Culture & PCR → Identifies Aspergillus species directly from sputum or bronchoalveolar lavage (BAL).
Chest CT Scan → Helps visualize aspergillomas, cavities, or nodules.


Next Steps if Positive

🔹 Evaluate clinical symptoms & risk factors (e.g., chronic lung disease, immunosuppression).
🔹 Consider further testing (CT scan, fungal culture, galactomannan test).
🔹 Initiate antifungal treatment if indicated (e.g., itraconazole, voriconazole for CPA or ABPA).

Original price was: ₹1,750.00.Current price is: ₹1,399.00.

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