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The Coeliac Fusion Test is a combined blood test used to diagnose Coeliac Disease (Celiac Disease) by detecting antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP). This test is useful for both initial screening and monitoring of the disease.
✅ Anti-tTG IgA – Most sensitive and specific test for coeliac disease
✅ Anti-tTG IgG – Used when IgA deficiency is suspected
✅ Anti-DGP IgA & IgG – Useful for detecting early-stage coeliac disease or cases where tTG is negative
🔹 To Diagnose Coeliac Disease – Autoimmune reaction to gluten
🔹 To Monitor Disease Progression – Ensuring a gluten-free diet is effective
🔹 To Identify IgA Deficiency Cases – Some patients may have low IgA, affecting standard tests
| Test Result | Possible Meaning |
|---|---|
| High tTG IgA | Strong indication of coeliac disease |
| High tTG IgG | Possible coeliac disease, especially in IgA-deficient individuals |
| High DGP IgA/IgG | Suggests coeliac disease, even if tTG is negative |
| Normal or Low Levels | Unlikely to have coeliac disease (but further testing may be needed) |
🔹 Total IgA Test – Checks for IgA deficiency, which affects test accuracy
🔹 Endoscopy & Intestinal Biopsy – Confirms diagnosis if blood tests are positive
🔹 HLA-DQ2/DQ8 Genetic Testing – Determines genetic risk for coeliac disease
✅ Start a strict Gluten-Free Diet (GFD) 🍞🚫
✅ Consult a Gastroenterologist for further evaluation
✅ Monitor Antibody Levels after dietary changes
✅ Check for Nutritional Deficiencies (Iron, Vitamin B12, Folate, Calcium)