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The Hepatitis E Virus (HEV) Total Antibody Test detects both IgM and IgG antibodies against the Hepatitis E virus. This test helps determine if a person has a current, recent, or past HEV infection.
✅ Diagnose Acute or Past Hepatitis E Infection – Identifies whether a person currently has or has previously been infected with HEV.
✅ Assess Immunity to HEV – A positive IgG result suggests past exposure and possible immunity.
✅ Screening in Outbreak Areas – HEV is common in regions with poor sanitation and contaminated water supplies.
✅ Testing for Unexplained Liver Disease – HEV can cause acute hepatitis and sometimes lead to severe liver damage, especially in pregnant women or immunocompromised individuals.
🩸 Blood Sample Collection – A blood sample is taken and tested using ELISA (enzyme-linked immunosorbent assay) or immunoassay techniques.
| Result | Interpretation |
|---|---|
| IgM Positive, IgG Negative | Recent or active HEV infection. Further testing (HEV RNA PCR) may be needed. |
| IgM Positive, IgG Positive | Ongoing or recent HEV infection. Needs medical evaluation. |
| IgM Negative, IgG Positive | Past HEV infection, likely immune to reinfection. |
| IgM Negative, IgG Negative | No evidence of past or current HEV infection. |
📌 If an active infection is suspected, an HEV RNA PCR test may be recommended to detect the virus directly.
🔹 Fecal-Oral Route – Consuming contaminated food or water.
🔹 Undercooked Pork/Wild Animal Meat – A source of HEV infection in some regions.
🔹 Person-to-Person Transmission – Rare but possible in certain conditions.
🔹 Blood Transfusions & Organ Transplants – Rarely, HEV can be transmitted through infected blood.
⚠ Acute HEV Symptoms (2–6 weeks after exposure):
🔸 Fever, nausea, vomiting
🔸 Fatigue, loss of appetite
🔸 Abdominal pain
🔸 Jaundice (yellowing of skin/eyes)
🔸 Dark urine, pale stools
⚠ Severe Cases (especially in pregnant women & immunocompromised individuals):
🔸 Liver failure
🔸 Neurological complications
🔸 Higher risk of mortality in pregnancy (especially in the 3rd trimester)
🔬 HEV RNA PCR Test – Detects active HEV infection by identifying the virus in blood or stool.
🔬 Liver Function Tests (LFTs) – Checks for liver damage (elevated ALT, AST, bilirubin).
🔬 HEV IgM & IgG Separate Testing – Helps distinguish between recent and past infection.
✔ HEV Total Antibody Test detects both recent (IgM) and past (IgG) infections.
✔ IgG positivity suggests past infection and possible immunity.
✔ Pregnant women, transplant recipients, and people with liver disease are at higher risk of complications.
✔ Prevention includes proper sanitation, clean drinking water, and avoiding undercooked meat.