The NMO & MOG Antibodies Profile includes tests for:
1️⃣ Aquaporin-4 (AQP4) IgG – Associated with Neuromyelitis Optica Spectrum Disorder (NMOSD)
2️⃣ Myelin Oligodendrocyte Glycoprotein (MOG) IgG – Associated with MOG-Associated Disease (MOGAD)
These tests help diagnose and differentiate between NMOSD, MOGAD, and Multiple Sclerosis (MS), as they can present with similar symptoms but require different treatments.
✅ Diagnose Neuromyelitis Optica Spectrum Disorder (NMOSD) → AQP4-IgG Positive
✅ Diagnose MOG-Associated Disease (MOGAD) → MOG-IgG Positive
✅ Differentiate NMOSD, MOGAD, and MS
✅ Evaluate Causes of Optic Neuritis, Transverse Myelitis, and Brainstem Syndromes
✅ Guide Treatment Decisions – As MS and NMOSD/MOGAD require different therapies
| Test Result | Interpretation | Associated Condition |
|---|---|---|
| AQP4-IgG Positive | Confirms NMOSD | Neuromyelitis Optica Spectrum Disorder |
| MOG-IgG Positive | Confirms MOGAD | MOG-Associated Disease |
| Both Negative | NMOSD/MOGAD unlikely | Possible MS or another cause |
📌 NMOSD is typically AQP4-IgG positive (~70-80% of cases).
📌 MOGAD is typically MOG-IgG positive (~50-80% of cases).
📌 A negative test does NOT fully rule out NMOSD or MOGAD.
| Feature | NMOSD (AQP4-IgG Positive) | MOGAD (MOG-IgG Positive) | Multiple Sclerosis (MS) |
|---|---|---|---|
| Antibody | AQP4-IgG | MOG-IgG | Oligoclonal Bands (CSF) |
| Affected Areas | Optic nerve, spinal cord, brainstem | Optic nerve, brain, spinal cord | Brain, spinal cord |
| Optic Neuritis (ON) | Severe, often bilateral | Unilateral, milder, good recovery | Unilateral, variable severity |
| Spinal Cord Lesions | Long lesions (≥3 vertebrae) | Shorter lesions | Short, scattered lesions |
| Relapses | Severe, incomplete recovery | Frequent, better recovery | Frequent but milder progression |
| Treatment | Immunosuppressants (e.g., Rituximab) | Corticosteroids, IVIG | MS therapies (Interferons, Fingolimod) |
🔬 Additional Tests:
✔ MRI Brain & Spine – To check lesion patterns
✔ Lumbar Puncture (CSF Analysis) – Oligoclonal bands (present in MS, rare in NMOSD)
✔ Evoked Potentials – Assesses nerve damage
💊 Treatment Options:
Original price was: ₹8,500.00.₹7,499.00Current price is: ₹7,499.00.