Phosphatidylserine IgG Antibody Test

The Phosphatidylserine IgG Antibody Test detects IgG antibodies against phosphatidylserine, a type of phospholipid found in cell membranes. It is primarily used to diagnose Antiphospholipid Syndrome (APS), an autoimmune disorder that increases the risk of blood clotting and pregnancy complications.

Why is the Test Done?

✅ Diagnose Antiphospholipid Syndrome (APS) – A condition causing blood clots and pregnancy loss
✅ Investigate unexplained blood clots (deep vein thrombosis, pulmonary embolism, stroke)
✅ Assess recurrent miscarriages or pregnancy complications
✅ Evaluate autoimmune conditions like lupus (SLE)

Normal Range & Interpretation

📌 A single positive result is not enough for an APS diagnosis. Repeat testing after 12 weeks is required for confirmation.

Conditions Associated with High Phosphatidylserine IgG

🔹 Antiphospholipid Syndrome (APS) – Causes blood clots and pregnancy loss
🔹 Systemic Lupus Erythematosus (SLE) – Autoimmune disorder affecting multiple organs
🔹 Chronic Infections – Some infections can trigger temporary antibody production
🔹 Other Autoimmune Diseases – Such as rheumatoid arthritis and multiple sclerosis

Symptoms Suggesting APS or Autoimmune Disease

⚠ Blood clotting symptoms:
✔ Deep vein thrombosis (DVT) – Leg swelling, pain
✔ Pulmonary embolism (PE) – Shortness of breath, chest pain
✔ Stroke or mini-stroke (TIA) – Sudden weakness, speech problems
✔ Recurrent miscarriages – Especially after 10 weeks of pregnancy

Next Steps After a Positive Test

🔬 Confirmatory Tests:
✔ Repeat Phosphatidylserine IgG after 12 weeks
✔ Check other APS markers:

• Phosphatidylserine IgM & IgA
• Lupus Anticoagulant (LA)
• Anti-Cardiolipin Antibodies
• Beta-2 Glycoprotein I Antibodies

💊 Treatment for APS (if diagnosed):
✔ Blood thinners (anticoagulants) – Warfarin, heparin
✔ Aspirin (low-dose) – Reduces clot risk
✔ Immunosuppressants (if linked to lupus)