The TPHA titre test measures the amount (titre) of antibodies against Treponema pallidum, the bacteria that causes syphilis. It is a quantitative test that helps determine whether the infection is active, past, or treated.
✅ To confirm a syphilis infection after an initial positive TPHA test
✅ To determine the stage of syphilis (active or past infection)
✅ To monitor treatment effectiveness (decreasing titres indicate successful treatment)
🔹 Reported as a dilution ratio (e.g., 1:80, 1:160, 1:320, etc.)
🔹 Higher numbers = more antibodies, indicating a more recent or active infection
| TPHA Titre | Interpretation |
|---|---|
| Negative (0 or <1:80) | No infection or very early stage |
| Low titre (1:80 – 1:320) | Past infection or early-stage syphilis |
| High titre (≥ 1:640) | Active or untreated syphilis |
| Falling titre | Successful treatment |
| Stable or rising titre | Persistent or reinfection |
✔ Perform RPR/VDRL tests – These check for active infection and treatment progress.
✔ Doctor evaluation – Based on symptoms and test results, treatment may be needed.
✔ Follow-up testing – To ensure antibody levels decrease after treatment.